"Clinical Genetics, Academic Medical Center"[submitter] AND "LEPR"[gen - ClinVar

	Variation	Gene (Protein Change)	Type (Consequence)	Condition	Classification, Review status
Select item 8523	NM_002303.6(LEPR):c.326A>G (p.Lys109Arg)	LEPR (K109R)	Single nucleotide variant (missense variant)	Monogenic Non-Syndromic Obesity +3 more	GBenign
Select item 487357	NM_002303.6(LEPR):c.370+16G>T	LEPR	Single nucleotide variant (intron variant)	Obesity due to leptin receptor gene deficiency +1 more	GBenign
Select item 8521	NM_002303.6(LEPR):c.668A>G (p.Gln223Arg)	LEPR (Q223R)	Single nucleotide variant (missense variant)	Monogenic Non-Syndromic Obesity +3 more	GBenign
Select item 297991	NM_002303.6(LEPR):c.1029T>C (p.Ser343=)	LEPR	Single nucleotide variant (synonymous variant)	not provided +2 more	GBenign/Likely benign
Select item 804985	NM_002303.6(LEPR):c.1285+20G>A	LEPR	Single nucleotide variant (intron variant)	not provided	GBenign/Likely benign
Select item 8524	NM_002303.6(LEPR):c.1968G>C (p.Lys656Asn)	LEPR (K656N)	Single nucleotide variant (missense variant)	Monogenic Non-Syndromic Obesity +3 more	GBenign/Likely benign
Select item 297999	NM_002303.6(LEPR):c.3019A>T (p.Ser1007Cys)	LEPR (S1007C)	Single nucleotide variant (missense variant)	Obesity due to leptin receptor gene deficiency +3 more	GConflicting classifications of pathogenicity
Select item 298000	NM_002303.6(LEPR):c.3057G>A (p.Pro1019=)	LEPR	Single nucleotide variant (synonymous variant)	Monogenic Non-Syndromic Obesity +3 more	GBenign

ClinVar